Study-unit MICROBIOLOGY
| Course name | Chemistry and technology of drugs |
|---|---|
| Study-unit Code | A002513 |
| Location | PERUGIA |
| Curriculum | Comune a tutti i curricula |
| Lecturer | Donatella Pietrella |
| Lecturers |
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| Hours |
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| CFU | 6 |
| Course Regulation | Coorte 2021 |
| Supplied | 2021/22 |
| Learning activities | Base |
| Area | Discipline mediche |
| Sector | MED/07 |
| Type of study-unit | Obbligatorio (Required) |
| Type of learning activities | Attività formativa monodisciplinare |
| Language of instruction | Italian |
| Contents | Cellular organization, metabolism and genetics of bacteria, fungi and viruses The microbial virulence factors and infection transmission routes. Infection control strategies (vaccines and antimicrobials). Disinfection and Sterilization Main microorganisms involved in human infections. |
| Reference texts | Medical Microbiology Patrick R Murray, Ken S. Rosenthal, Michael A. Pfaller. Elsevier |
| Educational objectives | The purpose of the present course is to acquire the following knowledge: Cellular organization, metabolism, genetics of microorganisms Positive and negative interactions between organism and man. Pathogenetic mechanisms of microbial infections; Vaccines in the containment of infection. Molecular targets for antimicrobial drugs Antibiotic resistance: mechanisms and prevention strategies |
| Prerequisites | For the understanding of the course the student should have basic knowledge of cellular and molecular biology, anatomy, physiology and biochemistry. |
| Teaching methods | Face-to-face |
| Other information | Recommended attendance |
| Learning verification modality | Progress assessments and final oral exam |
| Extended program | History of microbiology. Microorganisms prokaryotes and eukaryotes: characteristics. Classification and nomenclature of microorganisms. The gut flora. Biotechnology in the pharmaceutical field. Bacteriology: Structures of the bacterial cell. Classification and morphology of bacteria, bacterial metabolism. Spores. Bacterial metabolism and physiology: nutrition, respiration, fermentation. Bacterial growth counts of bacteria, growth curve, culture media. bacterial genetics (transduction, conjugation and transformation) and gene regulation mechanisms. Virulence factors: adhesins, capsule, exoenzymes, bacterial toxins (characteristics and mechanism of action), biofilm formation. Antibacterial drugs. Main classes (wall inhibitors and protein synthesis, transcription, DNA replication, bacterial metabolism inhibitors) and relevant bacterial resistance mechanisms. Antibiogram. Main bacteria of clinical interest (Clostridia, Staphylococci, Streptococci, Escherichia coli, Pseudomonas aeruginosa, Mycobacterium tuberculosis). Virology: Classification, structure and replication of viruses. viral pathogenesis. antiviral drugs. General principles for the laboratory diagnosis: serological and molecular diagnosis. Main human pathogenic viruses: orthomyxovirus, hepatitis viruses Mycology: Fungi General. pathogenicity mechanisms. superficial and deep mycosis. antifungal drugs. Transmission mode of infectious diseases Control strategies of infections: disinfection, sterilization. Vaccines and immune sera. |