Study-unit CRUG ANALYSIS II - MOD. I AND MOD. II
| Course name | Pharmacy |
|---|---|
| Study-unit Code | A001742 |
| Location | PERUGIA |
| Curriculum | Comune a tutti i curricula |
| CFU | 12 |
| Course Regulation | Coorte 2022 |
| Supplied | 2025/26 |
| Supplied other course regulation | |
| Type of study-unit | Obbligatorio (Required) |
| Type of learning activities | Attività formativa integrata |
| Partition |
DRUG ANALYSIS II - MOD. I
| Code | A001743 |
|---|---|
| Location | PERUGIA |
| CFU | 5 |
| Lecturer | Giuseppe Manfroni |
| Lecturers |
|
| Hours |
|
| Learning activities | Caratterizzante |
| Area | Discipline chimiche, farmaceutiche e tecnologiche |
| Sector | CHIM/08 |
| Type of study-unit | Obbligatorio (Required) |
DRUG ANALYSIS II - MOD. II
| Code | A001745 |
|---|---|
| Location | PERUGIA |
| CFU | 7 |
| Learning activities | Caratterizzante |
| Area | Discipline chimiche, farmaceutiche e tecnologiche |
| Sector | CHIM/08 |
| Type of study-unit | Obbligatorio (Required) |
Cognomi A-L
| CFU | 7 |
|---|---|
| Lecturer | Stefano Sabatini |
| Lecturers |
|
| Hours |
|
| Language of instruction | Italian |
| Contents | Calcination of organic, organometallic and inorganic drugs. Qualitative research of the following elements: carbon, hydrogen, nitrogen, sulfur, halogens. Solubility. Characterization of the following functional groups: carboxylic acids, alcohols, phenols, ethers, aldehydes and ketones, amines, amides, nitro group, amino acids. Search of the double bond and aromatic structure. Specific assays for recognition of: acetates, citrates, tartrates, lactates, benzoates, salicylates, xanthine derivatives, aminobenzensulpholfonamides and sugars. Practical exercises on the recognition of inorganic, organometallic and organic drugs enrolled in FU XII and EP 11. |
| Reference texts | References: - E. Camaioni - Compendio teorico-pratico di analisi farmaceutica. Riconoscimento delle sostanze solide iscritte nelle vigenti farmacopee - Editrice Bertoni - Handouts given by the teacher; - A. Carta, M. G. Mamolo , F. Novelli, S. Piras - Analisi Farmaceutica Qualitativa - Editrice EDISES Reference texts: - F. Savelli, O. Bruno, Analisi Chimico Farmaceutica, Ed. Piccin - Padova - F. CHIMENTI, Identificazione sistematica di composti organici, Ed. Grasso. - Vogel - Chimica organica pratica - Casa editrice ambrosiana - Italian Pharmacopoeia and XII. European Pharmacopoeia 11th Ed. |
| Educational objectives | Knowledge of basic practical analysis and instrumental techniques to perform a qualitative analysis of a drug. Ability to recognize, to apply techniques and methodologies for the development of a rational path that identifies a substance of pharmaceutical interest. Ability, based on experimental results, to interpret the information obtained and evaluate the results. Ability to use the specific language of this discipline and to present the results obtained and the methodologies used in a report clear, comprehensive and meaningful to completely describe the problem. The student will be guided through a logical pathway that will enable him to identify virtually all compounds of pharmaceutical interest enrolled in F.U. XII and EP 11. |
| Prerequisites | In order to gain access to the course, the student will have to comply with the pre-requisites both general and the frequency and between examinations provided by the current Regolamento Didattico del Corso di Laurea Magistrale in Farmacia (https://dsf.unipg.it/files/clmfarm/2025-26/clm_fa_reg._did._2025-2026.pdf) |
| Teaching methods | The course is organized as follows: - Lectures on all the subjects of the course. - laboratory exercise, chronologically related to lectures, devoted to the learning of the basic analytical practical and instrumental techniques aimed to the execution of the qualitative analysis of compounds of pharmaceutical interest. Students will be divided, according to their number, in groups of about 25. Each of the 10 practical lessons will have a duration of about 5 hours for an amount of 45 hours/student. |
| Other information | Mandatory attendance at least at 80% of both practical and theoretical lectures. |
| Learning verification modality | - Final Practice Test in which to the student will be asked to identify two drugs registered in the existing Official Pharmacopoeia (1 organometallic and 1 organic drugs); - Oral examination in which the teacher verifies the student's mastery in resolving issues related to the qualitative analysis of drugs. For information on support services for students with disabilities and/or DSA visit the page https://www.unipg.it/disabilita-e-dsa |
| Extended program | Course overview and outlines about the systematic analysis of pharmaceutical inorganic substances reported in the F.U. XII e EP 11. Characters: physical state, color, and smell. Calcination of inorganic, metal-organic and organic substances with examples of substances that show particular properties (e.g., sublimation). Solubility: definition, expression, factors that influence the solubility: temperature, purity, chemical nature, and structure such as: polarity, hydrogen bond formation, molecular weight variation in a homologous series, melting point, structural isomerism, degree of ionization. Elemental analysis: detection of carbon and hydrogen atoms; Lassaigne test: detection of sulfur, nitrogen, halogens, and phosphorus; Beilstein test. Functional groups analysis: determination of unsaturated C-C bonds and aromatic system, alcohols, phenols, aldehydes and ketones, carboxylic acids and derivatives, amines, amino acids and, nitro derivatives. Systematic analysis of pharmaceutical organo-metallic substances inserted in F.U. XII e EP 11: general scheme and tables. Recognition of organo-metallic and organic salts: acetates, benzoates, salicylates, lactates, gluconates, citrates, and tartrates. Systematic analysis of pharmaceutical organic substances reported in F.U. XII and EP 11: solubility in water, ethyl ether, acids, and bases; solubility classification; neutral, acid, or basic drug properties (general scheme and tables). Analytical profile, recognition reactions and sorting of several classes of pharmaceutical compounds reported in F.U. XII and EP 11: Specific tests for carbohydrates, polyalcohols, sulphonamides, xanthines, amino acids, parabens, saccharin and others. Determination of physico-chemical constants: melting point, specific rotation, and absorbance (1%/1cm). IR Spectra. Chromatography: general aspects and principles of chromatographic separations of complex mixtures, chromatographic parameters, stationary and mobile phases, types of chromatography, diffusion parameters and Van Deemter's law; resolution in chromatography; elution modes. - HPLC: the stationary phases and their size and packing, apparatus needed (pumps, injectors, column, and detectors), normal and reverse phases, eluting methods, UV, fluorescence, and refractive index detectors. |
| Obiettivi Agenda 2030 per lo sviluppo sostenibile | 3, 4, 8 |
Cognomi M-Z
| CFU | 7 |
|---|---|
| Lecturer | Stefano Sabatini |
| Lecturers |
|
| Hours |
|
| Language of instruction | Italian |
| Contents | Calcination of organic, organometallic and inorganic drugs. Qualitative research of the following elements: carbon, hydrogen, nitrogen, sulfur, halogens. Solubility. Characterization of the following functional groups: carboxylic acids, alcohols, phenols, ethers, aldehydes and ketones, amines, amides, nitro group, amino acids. Search of the double bond and aromatic structure. Specific assays for recognition of: acetates, citrates, tartrates, lactates, benzoates, salicylates, xanthine derivatives, aminobenzensulpholfonamides and sugars. Practical exercises on the recognition of inorganic, organometallic and organic drugs enrolled in FU XII and EP 11. |
| Reference texts | References: - E. Camaioni - Compendio teorico-pratico di analisi farmaceutica. Riconoscimento delle sostanze solide iscritte nelle vigenti farmacopee - Editrice Bertoni - Handouts given by the teacher; - A. Carta, M. G. Mamolo , F. Novelli, S. Piras - Analisi Farmaceutica Qualitativa - Editrice EDISES Reference texts: - F. Savelli, O. Bruno, Analisi Chimico Farmaceutica, Ed. Piccin - Padova - F. CHIMENTI, Identificazione sistematica di composti organici, Ed. Grasso. - Vogel - Chimica organica pratica - Casa editrice ambrosiana - Italian Pharmacopoeia and XII. European Pharmacopoeia 11th Ed. |
| Educational objectives | Knowledge of basic practical analysis and instrumental techniques to perform a qualitative analysis of a drug. Ability to recognize, to apply techniques and methodologies for the development of a rational path that identifies a substance of pharmaceutical interest. Ability, based on experimental results, to interpret the information obtained and evaluate the results. Ability to use the specific language of this discipline and to present the results obtained and the methodologies used in a report clear, comprehensive and meaningful to completely describe the problem. The student will be guided through a logical pathway that will enable him to identify virtually all compounds of pharmaceutical interest enrolled in F.U. XII and EP 11. |
| Prerequisites | In order to gain access to the course, the student will have to comply with the pre-requisites both general and the frequency and between examinations provided by the current Regolamento Didattico del Corso di Laurea Magistrale in Farmacia (https://dsf.unipg.it/files/clmfarm/2025-26/clm_fa_reg._did._2025-2026.pdf) |
| Teaching methods | The course is organized as follows: - Lectures on all the subjects of the course. - laboratory exercise, chronologically related to lectures, devoted to the learning of the basic analytical practical and instrumental techniques aimed to the execution of the qualitative analysis of compounds of pharmaceutical interest. Students will be divided, according to their number, in groups of about 25. Each of the 10 practical lessons will have a duration of about 5 hours for an amount of 45 hours/student. |
| Other information | Mandatory attendance at least at 80% of both practical and theoretical lectures. |
| Learning verification modality | - Final Practice Test in which to the student will be asked to identify two drugs registered in the existing Official Pharmacopoeia (1 organometallic and 1 organic drugs); - Oral examination in which the teacher verifies the student's mastery in resolving issues related to the qualitative analysis of drugs. For information on support services for students with disabilities and/or DSA visit the page https://www.unipg.it/disabilita-e-dsa |
| Extended program | Course overview and outlines about the systematic analysis of pharmaceutical inorganic substances reported in the F.U. XII e EP 11. Characters: physical state, color, and smell. Calcination of inorganic, metal-organic and organic substances with examples of substances that show particular properties (e.g., sublimation). Solubility: definition, expression, factors that influence the solubility: temperature, purity, chemical nature, and structure such as: polarity, hydrogen bond formation, molecular weight variation in a homologous series, melting point, structural isomerism, degree of ionization. Elemental analysis: detection of carbon and hydrogen atoms; Lassaigne test: detection of sulfur, nitrogen, halogens, and phosphorus; Beilstein test. Functional groups analysis: determination of unsaturated C-C bonds and aromatic system, alcohols, phenols, aldehydes and ketones, carboxylic acids and derivatives, amines, amino acids and, nitro derivatives. Systematic analysis of pharmaceutical organo-metallic substances inserted in F.U. XII e EP 11: general scheme and tables. Recognition of organo-metallic and organic salts: acetates, benzoates, salicylates, lactates, gluconates, citrates, and tartrates. Systematic analysis of pharmaceutical organic substances reported in F.U. XII and EP 11: solubility in water, ethyl ether, acids, and bases; solubility classification; neutral, acid, or basic drug properties (general scheme and tables). Analytical profile, recognition reactions and sorting of several classes of pharmaceutical compounds reported in F.U. XII and EP 11: Specific tests for carbohydrates, polyalcohols, sulphonamides, xanthines, amino acids, parabens, saccharin and others. Determination of physico-chemical constants: melting point, specific rotation, and absorbance (1%/1cm). IR Spectra. Chromatography: general aspects and principles of chromatographic separations of complex mixtures, chromatographic parameters, stationary and mobile phases, types of chromatography, diffusion parameters and Van Deemter's law; resolution in chromatography; elution modes. - HPLC: the stationary phases and their size and packing, apparatus needed (pumps, injectors, column, and detectors), normal and reverse phases, eluting methods, UV, fluorescence, and refractive index detectors. |
| Obiettivi Agenda 2030 per lo sviluppo sostenibile | 3, 4, 8 |