Study-unit PHARMACOLOGY AND PHARMACOTHERAPY I
| Course name | Pharmacy |
|---|---|
| Study-unit Code | A003162 |
| Location | PERUGIA |
| Curriculum | Comune a tutti i curricula |
| Lecturer | Maria Teresa Pallotta |
| Lecturers |
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| Hours |
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| CFU | 12 |
| Course Regulation | Coorte 2022 |
| Supplied | 2024/25 |
| Learning activities | Caratterizzante |
| Area | Discipline biologiche e farmacologiche |
| Sector | BIO/14 |
| Type of study-unit | Obbligatorio (Required) |
| Type of learning activities | Attività formativa monodisciplinare |
| Language of instruction | Italian |
| Contents | Pharmacokinetics: disposition and metabolisms of drugs. Drug development, evaluation of new drugs and principles of therapeutics. |
| Reference texts | R. Paoletti, S. Nicosia, F Clementi, G. Fumagalli. Farmacologia generale e molecolare, UTET, Torino and L. Annunziato & G. DI RENZO TRATTATO DI FARMACOLOGIA IDELSON GNOCCHI Ed. – TERZA EDIZIONE |
| Educational objectives | The main objective of the course is to provide the student with the pharmacological basis for understanding other courses, such as Pharmacotherapy II, Molecular Basis of Biopharmaceuticals and Toxicology. General Pharmacology is the study of the fundamentals of the action of drugs, it evaluates the relationship between organism and drug and analyzes the general mechanisms of the interaction between the two systems. All drugs share general principles of action that regardless of the nature of the effect and which are common to all. The main knowledge acquired will be related to pharmacokinetics and pharmacodynamics, i.e.: absorption, distribution, metabolism, and elimination of drugs; routes of administration; bioavailability and bioequivalence; drug receptors; receptor activation theories. The knowledge acquired will allow the student to achieve the following skills: 1) be able to calculate the correct dosage of a drug 2) understand the mechanism of action of drugs 3) understand the dose-effect relevance 4) avoid toxic effects 5) use drugs rationally and achieve maximum effectiveness with minimal toxicity |
| Prerequisites | To effectively follow and understand the topics covered in the course, the student must have successfully passed the Biochemistry and Physiology exams. Knowledge of these topics is essential for the student who wants to follow the course profitably. |
| Teaching methods | Face-to-face teaching |
| Other information | Students with disabilities and/or DSA are invited to visit the page dedicated to the tools and measures envisaged and to agree in advance what is necessary with the teacher (https://www.unipg.it/disabilita-e -dsa) |
| Learning verification modality | Oral exam, aimed at determining knowledge of both pharmacokinetics and pharmacodynamics, which are the fundamental elements for the correct use and design of a drug |
| Extended program | Introduction to pharmacology. Concept of drug and medication. Chemical and physical properties of drugs. Pharmacokinetics: the dynamic of drug absortion, distribution, metabolism and elimination. Routes of administration Pharmacodynamics - Molecular drug targets - Families of receptors and signaling pathways - Quantitation of drug-receptor interaction and effects, radioligand binding method, molecular characterization (ion channels, G-protein-coupled receptor, receptor protein kinases, intracellular receptors). - Transcription factors. - Agonist and antagonist ligands - Regulation of receptors - Pharmacogenomics and pharmacogenetics |