Study-unit BIOTECHNOLOGICAL APPROACHES TO ONCOLOGICAL DISEASES
| Course name | Medical, veterinary and forensic biotechnological sciences |
|---|---|
| Study-unit Code | A001772 |
| Curriculum | Medico |
| Lecturer | Sonia Moretti |
| Lecturers |
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| Hours |
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| CFU | 6 |
| Course Regulation | Coorte 2022 |
| Supplied | 2023/24 |
| Supplied other course regulation | |
| Learning activities | Caratterizzante |
| Area | Discipline medico-chirurgiche e riproduzione umana |
| Sector | MED/46 |
| Type of study-unit | Opzionale (Optional) |
| Type of learning activities | Attività formativa monodisciplinare |
| Language of instruction | English |
| Contents | "Hallmarks of Cancers". Oncogenes and Tumor suppressor Genes. Thyroid cancers. Oncogenes in thyroid cancer (RET/PTC, RAS, BRAF e TERT). Screening methods for the detection of mutations. Study of DNA and RNA with high-throughput technologies (NGS, Nanostring, Microarray). Study of proteins with high-throughput technologies (RPPA, Proteomics, Mass-spectrometry). Radiation-induced oncogenesis: lesson from Chernobyl. Cancer Biomarkers: diagnostic, prognostic and predictive biomarkers. Personalized cancer therapies and targeted therapies. Immune-oncology and immunotherapy in cancer (Immune Checkpoint Inhibitors and cancer vaccines). Adoptive cell transfer. Immune-oncology of thyroid cancers. |
| Reference texts | A reference text is not available. The teacher will provide the didactic materials, consisting mainly of articles of scientific literature. |
| Educational objectives | The course aims to provide students with an integrated view of the biotechnological approach to oncological diseases. This objective will be achieved studing the molecular mechanisms involved in the development and progression of cancer, the biotechnological techniques useful for the molecular characterization of cancer and the importance of the latter in the diagnosis and therapy. |
| Prerequisites | General Biology, Molecular Biology, Principles of Immunology and General Physiology, Genetics |
| Teaching methods | The teaching activity is carried out through lectures with the support of Power Point slides. The laboratory practical lessons will take place in small groups at the Thyroid Genomics and Proteomics laboratory (Dept. Medicine and Surgery) |
| Other information | Students will be provided with the slides used during the lessons. |
| Learning verification modality | Oral examination. For information on support services for students with disabilities and/or specific learning disorders visit the page http://www.unipg.it/disabilita-e-dsa |
| Extended program | "Hallmarks of Cancers". Study of the principal oncogenes and Tumor suppressor Genes. Thyroid cancers and oncogenes involved in thyroid cancer (RET/PTC, RAS, BRAF e TERT). Mutation and screening methods for the detection of mutations (SSCP, DGGE and its variants, HA, D-HPLC, Sanger sequencing). Study of high-throughput technologies for the analysis of macromolecules (DNA, RNA and proteins), in particular, main techniques of NGS, Nanostring, Microarray, RPPA, Proteomics, Mass-spectrometry. Radiation-induced oncogenesis: lesson from Chernobyl. Cancer Biomarkers: diagnostic, prognostic and predictive biomarkers. Analytic validation of biomarkers: sensitivity, specificity, NPV, PPV. Personalized cancer therapies and targeted therapies. Oncogene addiction theory. Immune system and cancer. Immune-oncology and immunotherapy in cancer (Immune Checkpoint Inhibitors and cancer vaccines). Adoptive cell transfer. Immune-oncology of thyroid cancers. |
| Obiettivi Agenda 2030 per lo sviluppo sostenibile | 3: Good health and well-being |